Anti-Human GD2 Recombinant Antibody (hu14.18K322A)
CAT#: TAB-304CL
Recombinant Humanized monoclonal antibody expressed in CHO binding to Human GD2. Hu14.18K322A is a monoclonal antibody that is made to bind to cancer cells that have a molecule called GD2 on their surface, designed to decrease toxicity in children with refractory or recurrent neuroblastoma.
Published Data
Tested Data
FC
Figure 1 A flow cytometry histogram showing binding of hu14.18K322A to B78D14 tumor cells.
The bold and thin lines represent isotype control and PE secondary only control, respectively. The shaded area is binding of hu14.18K322A.
Alderson, K. L., Luangrath, M., Elsenheimer, M. M., Gillies, S. D., Navid, F., Rakhmilevich, A. L., & Sondel, P. M. (2013). Enhancement of the anti-melanoma response of Hu14. 18K322A by αCD40+ CpG. Cancer Immunology, Immunotherapy, 62(4), 665-675.
FuncS
Figure 2 C57BL/6 mice were implanted subcutaneously with 0.5×10⁶ B78D14 tumor cells on day 0, and therapy was initiated 5 days after tumor cell implantation.
Tumor cell growth was followed after cessation of immunotherapy (and plotted based on the days after tumor implantation). Tumor growth analyses consist of 6-8 mice per group and are representative of at least three independent experiments.
Alderson, K. L., Luangrath, M., Elsenheimer, M. M., Gillies, S. D., Navid, F., Rakhmilevich, A. L., & Sondel, P. M. (2013). Enhancement of the anti-melanoma response of Hu14. 18K322A by αCD40+ CpG. Cancer Immunology, Immunotherapy, 62(4), 665-675.
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SDS-PAGE
Figure 1 Anti-Human GD2 Recombinant Antibody (TAB-304CL) in SDS-PAGE
Lane 1: Reduced mAb
Lane 2: Non-reduced mAb
SEC-HPLC
Figure 2 Anti-Human GD2 Recombinant Antibody (TAB-304CL) in HPLC
The purity of TAB-304CL was greater than 95% as determined by HPLC.
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Specifications
- Derivation
- Humanized
- Type
- Antibody
- Species Reactivity
- Human
- Applications
- FC, FuncS
- Related Disease
- Neuroblastoma
Product Property
- Purity
- >90% assessed by SDS-PAGE
- Storage
- ≥1 year at -20°C. If the reconstituted antibody cannot be used within two weeks, it should be aliquoted into smaller vials and stored at -20°C
Applications
- Application Notes
- This antibody has been reported for use in Flow Cytometry and Function Assay.
Target
- Alternative Names
- GD2 ganglioside; GD2
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(Creative Biolabs Cat# TAB-304CL, RRID: AB_3111908)
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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COA
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| TAB-075CQ-S(P) | Human Anti-GD2 Recombinant Antibody; scFv Fragment (TAB-075CQ-S(P)) | ELISA, FC | Human scFv |
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| CAT | Product Name | Application | Type |
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